Isocitrate dehydrogenases are enzymes that catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD (+) as the electron acceptor and the other NADP (+).

Aug 31, 2022 · What Is an Isocitrate Dehydrogenase-2 (IDH2) Mutation? The isocitrate dehydrogenase-2 (IDH2) mutation is associated with some types of cancer such as acute myeloid leukemia (AML), myelofibrosis, and brain cancer (glioma), as well as some genetic conditions.

Dec 25, 2024 · IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) is a Protein Coding gene. Diseases associated with IDH2 include D-2-Hydroxyglutaric Aciduria 2 and Multiple Enchondromatosis, Maffucci Type. Among its related pathways are Citric acid cycle (TCA cycle) and Transcriptional activation of mitochondrial biogenesis.

The IDH2 gene provides instructions for making an enzyme called isocitrate dehydrogenase 2. Learn about this gene and related health conditions.

IDH2, a novel target of OGT, facilitates glucose uptake and cellular bioenergy production via NF-kappaB signaling to promote colorectal cancer progression. IDH2 stabilizes HIF-1alpha-induced metabolic reprogramming and promotes chemoresistance in urothelial cancer.

IDH2 is a mitochondrial NADP-dependent isocitrate dehydrogenase (EC 1.1.1.42) that catalyzes oxidative decarboxylation of isocitrate to alpha-ketoglutarate, producing NADPH. By providing NADPH for NADPH-dependent antioxidant enzymes, IDH2 plays a major role in controlling the mitochondrial redox balance and mitigating cellular oxidative damage ...

Abnormal histone and DNA methylation are emerging as a common feature of tumors with IDH1 and IDH2 mutations and may cause altered stem cell differentiation and eventual tumorigenesis. Therapeutically, unique features of IDH1 and IDH2 mutations make them good biomarkers and potential drug targets.

Aug 10, 2017 · Recurrent mutations in isocitrate dehydrogenase 2 (IDH2) occur in ∼12% of patients with acute myeloid leukemia (AML). Mutated IDH2 proteins neomorphically synthesize 2-hydroxyglutarate resulting in DNA and histone hypermethylation, which leads to …

Jan 9, 2024 · IDH2, a novel target of OGT, facilitates glucose uptake and cellular bioenergy production via NF-κB signaling to promote colorectal cancer progression. He X, Wu N, Li R, Zhang H, Zhao Y, Nie Y, Wu JHe X, et al. Cell Oncol (Dordr), 2023 Feb. PMID 36401762

Oct 6, 2015 · Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes, converting isocitrate to &agr;-ketoglutarate (&agr;KG). IDH1 and IDH2 mutations have been identified in multiple tumor types, including gliomas and myeloid malignancies such as acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).