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Learn more about Bing search results hereFollicular Lymphoma Bcl 2
This summary was generated by AI from multiple online sources. Find the source links used for this summary under "Based on sources".
Learn more about Bing search results hereOrganizing and summarizing search results for youBcl-2 is a gene that is commonly involved in follicular lymphoma, a type of non-Hodgkin's lymphoma. In follicular lymphoma, a chromosomal translocation commonly occurs between the fourteenth and the eighteenth chromosomes, which places the Bcl-2 gene from chromosome 18 next to the immunoglobulin heavy chain locus on chromosome 14. This fusion gene is deregulated, leading to the transcription of excessively high levels of Bcl-2. Bcl-2 is an oncogene that blocks programmed cell death (apoptosis). Overexpression of Bcl-2 results in increased cell survival.5 Sources
BCL2 mutations are associated with increased risk of …
Jan 22, 2015 · Follicular lymphoma (FL), an indolent neoplasm caused by a t (14;18) chromosomal translocation that juxtaposes the BCL2 gene and immunoglobulin locus, has a …
- Author: Cristina Correia, Paula A. Schneider, Haiming Dai, Ahmet Dogan, Matthew J. Maurer, Amy K. Church, An...
- Publish Year: 2015
See results only from ashpublications.orgBCL-2 inhibition in follicular l…
VEN is a selective oral inhibitor of BCL-2 (BH-3 mimetic) that is currently …
BCL2 Negative Follicular Lym…
Follicular lymphoma (FL) is the most common indolent subtype of non …
Relationship between BCL2 mutations and follicular lymphoma …
May 17, 2023 · Building on a prior study demonstrating the early transformation of FLs with high variant allele frequency (VAF) BCL2 mutations at activation-induced cytidine deaminase …
BCL-2 inhibition in follicular lymphoma: can we tip the …
Dec 3, 2020 · VEN is a selective oral inhibitor of BCL-2 (BH-3 mimetic) that is currently approved for use in chronic lymphocytic leukemia (CLL) and acute myeloid leukemia. In 2017, Davids et al reported a phase 1 study of VEN in a …
BCL2 Negative Follicular Lymphoma with - American …
Nov 16, 2012 · Follicular lymphoma (FL) is the most common indolent subtype of non-Hodgkin's lymphoma in the western world. The genetic hallmark of FL is the t (14;18) (q32;q21) translocation leading to the deregulation of BCL2 …
Detection of BCL2 Rearrangements in Follicular Lymphoma
The distinction between follicular lymphoma and reactive hyperplasia should be based on morphological features (which are sufficient to diagnose follicular lymphoma in >80% of …
Diagnostic clues of BCL2-negative, faint, or controversial follicular ...
BCL2 positivity by immunohistochemistry is helpful for the diagnosis of follicular lymphoma (FL); however, a minority of FL cases are BCL2-negative, and the diagnosis is thus challenging. We …
BCL-2 Expression in Primary Cutaneous Follicle Center B-Cell …
BCL-2 is an antiapoptotic molecule and exerts its function by blocking pro-apoptotic stimuli leading to neoplastic cells survival, gaining advantages to tumor growth and spread (5). BCL-2 …
Expression of the bcl-2 gene product in follicular lymphoma.
Expression of bcl-2 protein was analyzed in 140 cases of follicular lymphoma by immunohistologic staining of paraffin-embedded tissue; 85% of cases were positive, the frequency being related …
BCL-2 Immunohistochemical Marker | Propath
Nov 10, 2022 · BCL-2 is a commonly used immunohistochemical marker, and it has utility in the classification of lymphoid processes, recognition of certain epithelial tumors, and also some …
Bcl-2 clearance: optimising outcomes in follicular non-Hodgkin's …
Molecular remission, as measured by bone-marrow bcl-2 clearance, has been achieved in 7/7 patients with follicular NHL at 1 year after treatment with ASCT using rituximab as an 'in …
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