The EMBO Journal

Role and mechanism of PVN–sympathetic–adipose circuit in depression and insulin resistance induced by chronic stress

Chronic stress induces depression and insulin resistance, between which there is a bidirectional relationship. However, the mechanisms underlying this comorbidity remain unclear. White adipose tissue ...
The EMBO Journal

Melanocyte differentiation and mechanosensation are differentially modulated by distinct extracellular matrix proteins

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Melanocyte dysfunctions can lead to ...
The EMBO Journal

DNA methylation at retrotransposons protects the germline by preventing NRF1-mediated activation

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Silencing evolutionary young retrotransposons ...
The EMBO Journal

PV-1: a novel molecular prognostic marker of distant metastases in various solid tumors

PH proportional hazards, HR hazard ratio, CI confidence interval. a Per 10-unit increase. b Per 1-cm increase. c pT3 vs. pT1-2 (reference). d III-IV vs. I–II (reference). e Per 10-year increase. Bold ...
The EMBO Journal

Determining the effects of pseudouridine incorporation on human tRNAs

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Transfer RNAs (tRNAs) are ubiquitous ...
The EMBO Journal

Proton conductance by human uncoupling protein 1 is inhibited by purine and pyrimidine nucleotides

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Uncoupling protein 1 (UCP1, SLC25A7) is ...
The EMBO Journal

Wengen’s hidden powers: ROS triggers a TNFR-dependent tissue regenerative pathway in Drosophila

While the role of the Tumor necrosis factor-α (referred to as TNF here) as a key mediator of pro-inflammatory and immune responses is well-established, non-pathological functions of the TNF-TNF ...
The EMBO Journal

Pharmacological Gq inhibition induces strong pulmonary vasorelaxation and reverses pulmonary hypertension

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Pulmonary arterial hypertension (PAH) is a ...
The EMBO Journal

Dynamin 1xA interacts with Endophilin A1 via its spliced long C-terminus for ultrafast endocytosis

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Dynamin 1 mediates fission of endocytic ...
The EMBO Journal

Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa‐Porthos axis in Drosophila

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Cellular metabolism must adapt to changing ...
The EMBO Journal

PRODH safeguards human naive pluripotency by limiting mitochondrial oxidative phosphorylation and reactive oxygen species production

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Naive human embryonic stem cells (hESCs) that ...
The EMBO Journal

N4-acetylcytidine (ac4C) promotes mRNA localization to stress granules

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Stress granules are an integral part of the ...