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Variability in sensitivity to inflammation in muscle and lung of patients with COPD may underlie susceptibility to lung function decline
Background Muscle wasting and weakness (sarcopenia) are commonly associated with COPD causing frailty and reduced quality of ...
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Chronotherapy in asthma: BD or not BD? That is the question
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Airway function and markers of airway inflammation in patients with treated hypothyroidism
Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK Correspondence to: Dr S S Birring Institute for Lung Health, Department of Respiratory Medicine, ...
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How many times per day should peak expiratory flow rates be assessed when investigating occupational asthma?
BACKGROUND--Serial peak expiratory flow rate (PEF) recording has been advocated as a sensitive and specific means of confirming work related asthma. The optimum number of recordings per day to achieve ...
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Airway inflammation, basement membrane thickening and bronchial hyperresponsiveness in asthma
Background: There are few data in asthma relating airway physiology, inflammation and remodelling and the relative effects of inhaled corticosteroid (ICS) treatment on these parameters. A study of the ...
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P75 Patient experience of non-invasive ventilation: a qualitative study
Introduction Non-invasive ventilation (NIV) is an effective treatment for acute type 2 respiratory failure, often avoiding intubation and improving mortality. However many patients struggle to ...
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Dyspnoea severity and pneumonia as predictors of in-hospital mortality and early readmission in acute exacerbations of COPD
Background Rates of mortality and readmission are high in patients hospitalised with acute exacerbations of chronic obstructive pulmonary disease (AECOPD). In this population, the prognostic value of ...
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Chronic cough: from a complex dysfunction of the neurological circuit to the production of persistent cough
Chronic cough or cough that lasts more than 8 weeks, once a chest x-ray and spirometry are confirmed normal, is caused by an alteration in a section of the route between peripheral receptors, mainly ...
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Cardiovascular events in patients with COPD: TORCH Study results
Background Previous studies have suggested that long-term use of β agonists to treat chronic obstructive pulmonary disease (COPD) may increase the risk of cardiovascular adverse events. In this post ...
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Vasodilator-induced selective pulmonary oedema in sarcoidosis-associated pulmonary hypertension with pulmonary venous stenosis
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