1 Introduction. Sepsis is the most serious threat to human health worldwide, affecting more than 40 million people worldwide each year and killing roughly one in five of them ().Its core mechanism is ...

Immunosuppressive treatments in Behçet's disease: indications and side effects. Drugs Doses Molecular/cell targets Mechanism of action Main indications Main side effects/toxicity ...

A comparison of immunosuppressive therapies for the treatment of diffuse cutaneous systemic sclerosis found “robust” support for mycophenolate mofetil as the first-line standard of care ...

Two Chinese researchers were charged with smuggling a fungus classified “as a potential agroterrorism weapon” that could decimate crops and impact human health into the US last summer in a wad ...

CAFs Defang NK Cells to Promote Breast Cancer Immunosuppression Available to Purchase. Mara H. Sherman. 0000-0001-7826-3888 Mara H. Sherman * * Corresponding Author: Mara H. Sherman, Cancer Biology & ...

In a study published in Circulation Research, the team tested an experimental therapy in animal models based on immunosuppressive nanoparticles and demonstrated that it can slow disease progression.

Understanding and modulating the interplay between cancer cells and immune cells is critical for deciphering cancer progression and developing effective therapies. However, studying this interplay ...

A California cancer survivor was the recipient of the world's first in-human bladder transplant this month thanks to a pair of Los Angeles doctors.

APX-343A, a selective NOX1, NOX2, and NOX4 inhibitor, has been shown to ameliorate the fibrotic and immunosuppressive properties of CAFs. In CAF-rich tumor mouse models that do not respond to ICIs, ...

Diaporlabanoids A–C (1–3, respectively), three highly modified dinorlabdane diterpene alkaloids featuring an unprecedented succinimide-containing 6/6/6/5/5-fused pentacyclic skeleton, were obtained ...