Three major approaches were taken: large scale screening of mutant Medaka fish defective in embryogenesis; a Wnt family-focused in-depth investigation of signaling systems; and a modernized revisit to ...

Specifically we have been interested in characterizing the role of Wnt and Fgf family members in normal mammary gland development and stem cell self-renewal, and the properties of tumor initiating ...

Wnt signaling is an important developmental pathway, regulated by Wnt family growth factors (wingless is the Drosophila Wnt). In the absence of a Wnt signal, phosphorylation of β-catenin by ...

Vertebrate PCP involves Wnt family members, but it is not known whether this is instructive or permissive, whereas evidence from D. melanogaster indicates Fat, Dachsous and Four-jointed as ...