Specifically we have been interested in characterizing the role of Wnt and Fgf family members in normal mammary gland development and stem cell self-renewal, and the properties of tumor initiating ...

Vertebrate PCP involves Wnt family members, but it is not known whether this is instructive or permissive, whereas evidence from D. melanogaster indicates Fat, Dachsous and Four-jointed as ...

Wnt signaling is an important developmental pathway, regulated by Wnt family growth factors (wingless is the Drosophila Wnt). In the absence of a Wnt signal, phosphorylation of β-catenin by ...

Three major approaches were taken: large scale screening of mutant Medaka fish defective in embryogenesis; a Wnt family-focused in-depth investigation of signaling systems; and a modernized revisit to ...