Protein kinase C-α (PKCα) has been studied widely as a paradigm for conventional PKCs, with two C1 domains (C1A and C1B) being important for the regulation and function of the kinase. However, it is ...

At least 10 different types of globular protein domain are known that bind membrane phospholipids. Acidic phospholipids (especially phosphatidylserine and phosphoinositides) are the primary ...

In this study, the authors present a thorough mechanistic study of the J-domain protein Apj1 in Saccharomyces cerevisiae, establishing it as a key repressor of Hsf1 during the attenuation phase of the ...

the study uncovers a new regulatory role for a type of protein domains common in many nuclear proteins, but until now only poorly understood. The IDR in TAF2 steers the protein away from active ...

This valuable study focuses on defining how the HSP70 chaperone system utilizes J-domain proteins to regulate the heat shock response-associated transcription factor HSF1. Using a combination of ...

A special enzyme - the so-called ubiquitin-selective unfoldase p97/VCP - is one of the main players when cells remove malformed or excess proteins from their interior. This is the central finding of a ...

A special enzyme - the so-called ubiquitin-selective unfoldase p97/VCP - is one of the main players when cells remove malformed or excess proteins from their interior. This is the central finding ...

A special enzyme—the so-called ubiquitin-selective unfoldase p97/VCP—is one of the main players when cells remove malformed or excess proteins from their interior. This is the central finding ...

If the enzyme p97/VCP works properly, the cell is able to break down accumulations of misfolded proteins. They can be seen in the left image as white dots inside the cell. After blocking the ...

A special enzyme - the so-called ubiquitin-selective unfoldase p97/VCP - is one of the main players when cells remove malformed or excess proteins from their interior. This is the central finding of a ...