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Immune restraint through the ages: PD-1 pathway traced to sharks
In 1992, graduate student Yasumasa Ishida discovered PD-1, marking the beginning of a journey that would make this molecule a ...
C&EN6d
Interactions of Protein Kinase C-α C1A and C1B Domains with Membranes: A Combined Computational and Experimental Study
Protein kinase C-α (PKCα) has been studied widely as a paradigm for conventional PKCs, with two C1 domains (C1A and C1B) being important for the regulation and function of the kinase. However, it is ...
C&EN6d
Biochemical Characterization of Human SET and MYND Domain-Containing Protein 2 Methyltransferase
† Oncology Innovative Medicines Unit, AstraZeneca Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States ‡ DECS Structural Chemistry, AstraZeneca Pharmaceuticals, 35 ...