C57BL/6 mouse PK. Animals were dosed iv at 1 mg/kg; po at 5 mg/kg, n = 2; 10% 0.1 N HCl, 10% PG, 25 (20%) Solutol, 100 mM pH 5 citrate buffer formulation.

† Hoffmann-La Roche Inc., pRED, Pharma Research & Early Development, DTA Metabolism, 340 Kingsland Street, Nutley, New Jersey 07110, United States ‡ Department of Biochemistry and Diabetes Center, ...