In eukaryotic cells, a ubiquitin conjugation cascade pathway exists to enzymatically activate ubiquitin, which then becomes covalently attached to substrate proteins that are destined for proteolysis.

Among many examples are activation of transcription factor NF ... The early history of the ubiquitin field recapitulates, in a microcosm, the essential interaction between biochemistry and ...

Melbourne-based researchers at the Walter and Eliza Hall Institute (WEHI) at the Parkinson's Disease Research Centre have ...

The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and maintaining host immune homeostasis in the meantime. Here, ...

Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...

The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and ...