In eukaryotic cells, a ubiquitin conjugation cascade pathway exists to enzymatically activate ubiquitin, which then becomes covalently attached to substrate proteins that are destined for proteolysis.

A new study has uncovered a molecular mechanism by which rice cells perceive viral infections and initiate antiviral response ...

Among many examples are activation of transcription factor NF ... The early history of the ubiquitin field recapitulates, in a microcosm, the essential interaction between biochemistry and ...

The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and maintaining host immune homeostasis in the meantime. Here, ...

Melbourne-based researchers at the Walter and Eliza Hall Institute (WEHI) at the Parkinson's Disease Research Centre have ...

Though recent discoveries have revealed how rice plants mitigate such threats by initiating immune responses against ...

Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...

The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and ...