Introduction: GBA1 variants are significant genetic risk factors for Parkinson’s disease (PD). Accurately measuring glucocerebrosidase (GCase) activity is crucial for understanding disease progression ...

College of Biological and Pharmaceutical Engineering, Anhui Engineering Laboratory for Conservation and Sustainable Utilization of Traditional Chinese Medicine Resources, Anhui Province Key Laboratory ...

Ben-May Institute for Cancer Research, The University of Chicago, Chicago, United States Simons Electron Microscopy Center, New York Structural Biology Center, New York, United States Biophysics ...

Key Laboratory of Analytical Science for Food Safety and Biology (MOE & Fujian Province), Department of Chemistry, Fuzhou University, Fuzhou 350108, People’s Republic of China ...

Vorinostat is metabolized and excreted following glucuronidation by the uridine diphosphate glucuronosyl-transferase (UGT) enzyme system. Polymorphisms in the gene encoding for this enzyme system ...

Geriatric Diseases Institute of Chengdu, Center for Medicine Research and Translation, Chengdu Fifth People’s Hospital (The Second Clinical Medical College, Affiliated Fifth People’s Hospital of ...

TABLE 1. Kinetic parameters of E1, E2, and E3 by HLM, HIM, and expressed UGT enzymes (Mean ± SD). All experiments were performed in triplicate (n = 3). TABLE 2. Inhibitory parameters of natural ...