Every day, our bodies perform around 330 billion cell divisions to keep us alive and functioning. These divisions rely on the ...

Chunks of flipped DNA appear to accelerate evolution in fish. This discovery could reshape our understanding of how biodiversity arises. Scientists have discovered that segments of “flipped” DNA help ...

In the world of viral research, uncovering a virus’s weaknesses is often a painstaking process that requires years of ...

Researchers discovered that HSV-1 (herpes simplex virus) actively reshapes the 3D layout of human DNA within hours of ...

Researchers have discovered that the herpes virus reshapes the human genome’s architecture, rearranging its shape in ...

Researchers in Spain may have found the first potential treatment that stops an incurable virus found in 122million Americans ...

Viruses are entirely dependent on their hosts to reproduce. They ransack living cells for parts and energy and hijack the ...

DNA topoisomerase 1 is an enzyme present in all organisms, essential for cell proliferation. ... thus relaxing the topological stress generated during replication and transcription; ...

This fundamental role in cell life makes topoisomerase I an important target for cancer therapies: its inhibition leads to DNA strand breaks, preventing the replication of diseased cells.

A research group at the University of Bologna has identified, for the first time, the specific location and genomic context where DNA breaks occur due to the inhibition of the topoisomerase I protein.

Conversely, topoisomerase inhibitors prevent gyrase and topoisomerase IV from completing their catalytic cycles. This robs the cell of essential enzyme functions. Inhibition of gyrase can stall DNA ...