DNA topoisomerase enzymes facilitate DNA helix ... other proteins (not shown) are needed for DNA replication. These include a set of initiator proteins to begin each new replication fork at ...

This fundamental role in cell life makes topoisomerase I an important target for cancer therapies: its inhibition leads to ...

Onco-Innovations’ licensed technology demonstrates promise to enhance chemotherapy effectiveness by overcoming cancer cell resistance: Vancouver, BC Saturday, February 1, 2025, ...

Gepotidacin has an entirely new mechanism of action, inhibiting DNA replication via two different type II topoisomerase enzymes, which should make it harder for pathogens to develop resistance.

Bifunctional Compositions for the Treatment of Cancer .1 This drug, which is often used to treat malaria, is being repurposed by Armaceutica, Inc. to treat various types of cancer.

Meiosis reduces ploidy by following one round of DNA replication with two rounds of chromosome segregation ... regulation of TOP-2 in male and female meiosis. Type II DNA topoisomerases (Topo II) are ...

Accurate transmission of the genetic information requires complete duplication of the chromosomal DNA each cell division cycle. However, the idea that replication forks would form at origins of DNA ...

and topoisomerase IV (both Type II topoisomerases), which are required for bacterial DNA replication, transcription, repair, and recombination. <18yrs: usually not recommended. See full labeling.

Levofloxacin 5mg/mL; soln for slow IV infusion; preservative-free. Levofloxacin inhibits bacterial topoisomerase IV and DNA gyrase (both of which are type II topoisomerases), enzymes required for ...