Why is the thymus an important factor in this therapy, and how does it impact T-cell development? Our cell therapy SMART101 (allogeneic blood stem cell-derived T-cell progenitors) is designed to ...

Negative selection in fetal thymus clonally deletes many self-reactive T cells, permanently removing ... factor regulating genes implicated in Treg development was confirmed.

Researchers from the Wellcome Sanger Institute and their collaborators at Ghent University, Belgium, the National Institutes of Health's National Institute of Allergy and Infectious Diseases and ...

CD8 T cells lacking Tet1/3 preferentially differentiate into short-lived effector and effector memory cells following acute infection. Tet1/3 thus act as determinants of CD8 T cell fates by promoting ...

The thymus produces T cells, which help the body to fight infection ... research say their findings could be significant in the development of immune-boosting therapies for over-60s and those ...

Data now show that thymus-derived self-peptide-specific ... sites for B7H3 cell surface localization and T cell inhibition, followed by the development of N91/309 and N104/322 preferentially ...

T cells are produced in the thymus, a specialized organ of the immune system. During development, Treg cells are trained to recognize specific peptides, including self-peptides from the body.

He uses mouse models to study the thymus, the organ in which specialized immune cells called T cells mature. His goal is to apply his findings to develop new therapies to promote immunity in cancer ...

The Conference Forum announced that the Immuno-Oncology 360º (IO360º) Summit honored Crystal Mackall, MD, FAAP, FAACR, Stanford University, with the IO360º Lifetime Achievement Award for her ...

T cells are produced in the thymus, a specialized organ of the immune system. During development, Treg cells are trained to recognize specific peptides, including self-peptides from the body.