Regeneration, the ability to heal damaged or lost tissues, is both an everyday and a real-life superpower. Health research ...

CAR T-cell therapy targeting B-cell maturation antigen (BCMA) has become a game changer for patients with relapsed or ...

A model developed by LMU biophysicists demonstrates how biological processes form the convoluted internal architecture of the ...

However, recent studies have identified the thymus as a novel and promising source of Tregs, overcoming the abovementioned limitations. Currently, human thymus-isolated regulatory T cells (thyTregs) ...

Development of T cells in the thymus results in small populations of innate like T cells. Here the authors characterise a population of innate-like T cells in mice engineered to enable MHC class ...

(C-E) Percentages and absolute numbers of each T cells in thymus at 3 weeks after the last radiation. (C) ... Madan V, Schmidt M, Fink PJ, et al. Thymus-autonomous T cell development in the absence of ...

In contrast, universal CAR-T cell therapies can be made ahead of time, stored frozen and be readily available "off-the-shelf," greatly reducing the wait time before therapy can begin.

An international clinical trial shows an innovative CAR-T cell immunotherapy is promising against aggressive T cell cancers and has manageable side effects.

AbstractIn this study, we observe that in human and murine melanomas, T-cell activation abates hematopoietic prostaglandin-D2 synthase (HPGDS) transcription in tumor-associated macrophages (TAM) ...