For the past five years, researchers at Leipzig University have been working on fundamentally new methods for selectively ...

Cyclodipeptide synthases (CDPSs) catalyze the synthesis of diverse cyclodipeptides (CDPs) by utilizing two aminoacyl-tRNA (aa-tRNA) substrates in a sequential ping-pong reaction mechanism. Numerous ...

Mitochondrial dysfunction increases oxidative stress and depletes ATP in a variety of disorders. Several antioxidant therapies and drugs affecting mitochondrial biogenesis are undergoing investigation ...

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Theoretical research examining the electric field within the energy-making enzyme ATP synthase alludes to it having a much higher enzymatic efficiency than reported in textbooks. 1 Calculations of the ...

The patterns of this oxidative stress, including molecular targets and the form of oxidative modification, can vary widely. ... ATP Synthase Structure and Function. The ATP synthase enzyme itself is a ...

Since raising the activity of ATP synthase may boost mitochondrial respiration and energy production, a chemical agonist of ATP synthase would have high therapeutic potential in this regard.

In order to reduce costs, effect of initial ATP concentration (0–10 mmol L −1) on whole-cell catalytic synthesis of L-Asn was investigated. Without the addition of ATP, only 3.56 mmol L −1 of L-Asn ...

ATP isolation from other sources followed over the next 15 years. Koscak Maruyama at Chiba University (Japan) wrote a comprehensive review of the discovery and structure elucidation of ATP in 1987.

The structure of the bovine ATP synthase and the monomer-monomer interfaces in the membrane domains of dimers. ... A. Hahn et al., Structure of a complete ATP synthase dimer reveals the molecular ...

To be fully sure that this is how the permeability transition pore forms, one would need to solve the structure of ATP synthase during Calcium-induced transitions, which we are doing now.” Reference: ...