Despite its advantages, TALEN also faces some challenges. The construction of TALEN proteins can be time-consuming and labor-intensive compared to other gene editing tools like CRISPR-Cas9.

14 “What was most exciting about [TALENs] is how it brought in so many people into the gene editing field,” Gersbach said. In 2011, the University of Minnesota exclusively licensed the TALEN patent to ...

Cema-cel takes healthy donor T cells, and using a gene-editing technique called TALEN, it removes 2 genes, and thereby 2 proteins, from the donor’s T cells. One of those is CD52—that's just ...

Stril discusses the advantages of using healthy donor cells, the role of TALEN ® gene-editing technology in tackling immune rejection and the potential of allogeneic CAR T-cell therapy in treating not ...

In a recent publication, researchers from the Institute of Ocular Microsurgery applied clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 and transcription activator-like effector ...

Using Cellectis’ TALEN® gene editing technology, we developed ‘Smart CAR T cells’ with the ability to express a CAR-inducible IL-2 variant (IL-2v) immunocytokine, potentiated by tumor ...

Shipra Das, an immunooncologist at Cellectis, discussed a novel approach using transcription activation-like effector nucleases (TALENs) gene editing to overcome these ... Cellectis holds the patent ...