In addition, we discuss how post-translational modifications, including phosphorylation, ubiquitination, and proteolysis, shape CYLD’s function, unveiling the potential for therapeutic intervention.

Targeted protein degraders are characterized by their bifunctional nature, binding to both a target protein and a ligase to drive ubiquitination and catalytic degradation of the target through the ...

Apoptosis is a form of programmed cell death that eliminates excessive and damaged cells. It can be conducted by two ways: the extrinsic and the intrinsic (mitochondrial) pathways. The extrinsic death ...

Insilico Medicine’s research started with PandaOmics, an AI-driven biology engine that analyzed extensive datasets and identified TNIK (TRAF2 and NCK-interacting kinase) as a promising target for the ...