S.W. Chung and J.S. Kim equally contributed to this article as co-first authors. W.-M. Choi and K.M. Kim equally contributed to this article as co-corresponding authors.

Disturbance of Itch LLPS impairs the turnover of lipid droplets. We propose that the feedback regulation of ubiquitination and LLPS is a general mechanism for the modulation of HECT E3 ligases. Lipid ...

Background: Tumor necrosis factor (TNF) receptor associated factor-2 (TRAF2) is an E3 ubiquitin ligase and scaffolding protein that contribute to the progression of various malignant tumors. However, ...

Proinflammatory agonists provoke the expression of cell surface adhesion molecules on endothelium in order to facilitate leukocyte infiltration into tissues. Rigorous control over this process is ...

IRF3 activation was also abolished in cells lacking TRAF2, 5, and 6. These TRAF proteins promoted ubiquitination reactions that recruited NEMO to the MAVS signaling complex, leading to the activation ...