Identifying proteomic signatures of insulin resistance in fasting muscle offers insights for personalized type 2 diabetes ...

A review in Biomolecules and Biomedicine sheds light on how microRNAs (miRNAs)—small regulatory RNA molecules—play a central ...

Objective Based on Toll Like Receptor 4 (TLR4)/Nuclear Factor-κB (NF-κB) Exploring the effects of Licochalcone A (LCA) on the proliferation, invasion, and drug resistance of glioma cells through ...

Toll-like receptors trigger an innate immune response by activating signaling pathways that are dependent ... activities that are indispensable for TLR responses, another possible explanation ...

Liver injury remains a critical global health issue as it can lead to severe complications such as fibrosis, cirrhosis, and hepatocellular carcinoma.

ATP released from sympathetic efferent nerve terminals activates the NLRP3 inflammasome in cardiac nonimmune cells through stimulation of the P2X7 receptor, which, together with Toll-like receptor ...

We here investigated the therapeutic potential of the toll-like receptor 2/6 agonist macrophage-activating ... established endothelial cells as target cells for a TLR2/6-dependent pathway, we now ...

Imbalances in TLR signaling pathways can lead to chronic inflammatory conditions, autoimmune diseases, or immunodeficiency disorders, emphasizing the critical role of TLRs in mounting responses to ...

Various signaling pathways guide the organization of cells and tissues in the body. Among these is the Bone Morphogenetic Protein (BMP) pathway, which plays a vital role in instructing early ...

1Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia.