Y. Cho, S. Gorina, P.D. Jeffrey, N.P. Pavletich, "Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations," Science, 265:346-55, 1994. (Cited in more than 140 ...

p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

p53 lies at the hub of a vast signalling network. Polymorphisms in upstream activators, repressors or downstream effectors of p53 might individually modulate cancer risk or interact with ...

The fragile structure of p53 gene reveals why this crucial cancer defense is so easily compromised, shedding light on the genetic Achilles' heel of many tumors. In a recent perspective published ...