One example is antibodies against endothelial HSP60. 71,72 Immunization with Hsp65 (mimicking human HSP60), transfer of polyclonal IgG from Hsp65-BSA immunized animals, or transfer of polyclonal human ...

Figure 1 Schematic diagram of NAb-mediated protective mechanisms against SARS-CoV-2 infection.(A) Neutralization mechanisms: Following the binding of NAbs (via Fab) to the RBD of the S1 subunit of ...

Objective To compare acute treatment responses and long-term outcome in leucine-rich glioma-inactivated 1 (LGI1) antibody encephalitis. Methods Retrospective case series of 118 patients with LGI1 ...

BMS will co-develop and co-commercialize BioNTech’s bispecific antibody BNT327 for solid tumors in a deal worth up to $11.1B for the German biotech.

The initial data from the Phase I trial (NCT05652335) of JNJ-5322 shows that the trispecific antibody led to a 100% overall response rate (ORR) in 27 patients who were naïve to anti-BCMA/-GPRC5D ...

The first-in-class antibody-drug conjugate (ADC) pivekimab sunirine (PVEK) demonstrated promising efficacy and high response rates for patients with blastic plasmacytoid dendritic cell neoplasm ...

Results from a phase 1 study showed TEV-53408 reduced free serum IL-15 levels in healthy participants. The Food and Drug Administration (FDA) has granted Fast Track designation to TEV-53408, an ...

Spain offered the long-acting monoclonal antibody nirsevimab to all infants born from 1 April 2023. The UK offered maternal RSV vaccination from September 2023, with estimated coverage below 60%, and ...

To our knowledge, this is the first case of AE in which both anti-LGI1 and anti-mGluR2 antibodies were found to be positive in serum and CSF with negative tumor screening. Lai et al. first reported ...

Navigator is also advancing NAV-242, a next-generation, engineered anti-OX40L/TNFα antibody, with half-life-extension, which has the potential for optimized exposure and dosing profile to provide a ...