In 50 kidney transplant recipients, GLP-1 receptor agonist use led to a mean weight loss of 3 kg, a mean improvement in estimated glomerular filtration rate of 3·5 mL/min per 1·73 m 2, a median ...

G protein-coupled receptors (GPCRs), the largest family of membrane proteins, serve as primary targets for over 30% of FDA-approved drugs. While signaling bias among Gα subtypes is well characterized, ...

Vepdegestrant, a PROTAC estrogen receptor (ER) degrader, vs fulvestrant in ER-positive/human epidermal growth factor receptor 2 (HER2)–negative advanced breast cancer: Results of the global, ...

Interestingly, MmMYL3 is not the first myosin protein to be identified as a viral receptor. Previous studies have shown that non-muscle myosin IIA acts as a receptor for herpes simplex virus (Arii et ...

Vepdegestrant is an oral proteolysis-targeting chimera (PROTAC) estrogen receptor (ER) degrader that directly harnesses the ubiquitin–proteasome system.In this phase 3, open-label, randomized ...

But all opioid receptors are not the same. In the current study, the researchers targeted KOR, a subtype of opioid receptor that when activated can decrease synaptic dopamine levels by decreasing ...

Objectives To evaluate the safety, tolerability, pharmacokinetics (PK), biomarker response and efficacy of E6742 in a phase I/II study in patients with systemic lupus erythematosus (SLE).Methods Two ...

Discover how bitter taste receptors in the intestines affect aging. A new study identifies specific receptors linked to metabolic changes, inflammation, and lipid metabolism. Learn how these ...

More information: Farhad Dehkhoda et al, Constitutive ghrelin receptor activity enables reversal of dopamine D2 receptor signaling, Molecular Cell (2025). DOI: 10.1016/j.molcel.2025.05.005 Journal ...

A phase 3 trial of the androgen receptor ligand-directed degrader, BMS-986365, versus investigator’s choice in patients with metastatic castration-resistant prostate cancer (CA071-1000 - rechARge).