World Bank26d
Poverty, Prosperity, and Planet: Pathways Out of the Polycrisis
The "Poverty, Prosperity, and Planet. Pathways Out of the Polycrisis" report evaluates progress towards these goals. It offers the first global assessment of poverty and shared prosperity ...
World Bank1mon
New World Bank Report Highlights Four Pathways to Spur Job Creation and Inclusive Growth in South Africa
CAPE TOWN, February 28, 2025 — A new World Bank report titled “Driving Inclusive Growth in South Africa: Quick Wins with Competitive Markets and Efficient Institutions” asserts that a robust economic ...
Frontiers2y
A-910823, a squalene-based emulsion adjuvant, induces T follicular helper cells and humoral immune responses via α-tocopherol component
Background: Adjuvants are chemical or biological materials that enhance the efficacy of vaccines. A-910823 is a squalene-based emulsion adjuvant used for S-268019-b, a novel vaccine against severe ...
eLife2y
Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase
We previously showed that the rate-limiting and first oxygen-dependent enzyme of the committed cholesterol synthesis pathway, squalene monooxygenase (SM), can undergo partial proteasomal degradation ...
Frontiers4y
Current Challenges and Opportunities in Non-native Chemical Production by Engineered Yeasts
Synthetic pathways diverging from the distinctive cellular metabolism ... ERG20 (IspA), farnesyl pyrophosphate synthethase; SQS, squalene synthase; ADS, amorpha-4,11-diene synthase; CPR, cytochrome ...
eLife11y
Discovery of a metabolic alternative to the classical mevalonate pathway
Eukarya, Archaea, and some Bacteria encode all or part of the essential mevalonate (MVA) metabolic pathway clinically modulated using statins. Curiously, two components of the MVA pathway are often ...