Somatostatin receptors (SSTRs) constitute a crucial family of G protein-coupled receptors (GPCRs) that play pivotal roles in regulating hormone secretion and inhibiting tumor growth. Among five ...

Of note, some receptor subtypes are present in tissues where somatostatin is barely expressed ... to be equally potent in the inhibition of growth hormone release under basal conditions and ...

Somatotropic cells of the pituitary gland secrete GH, which is primarily controlled by growth hormone-releasing hormone (GHRH), produced by the hypothalamus to stimulate GH release; somatostatin ...

Paltusotine is a highly selective oral drug that activates somatostatin receptor subtype 2, decreasing levels of growth hormone and insulin-like growth factor 1 [IGF-1]. In the Phase 2 ACROBAT ...

In the study, which was supported by FAPESP, the researchers found that male mice lacking the GH receptor in a group of somatostatin ... raises the level of a hormone called ghrelin, a powerful ...

Growth hormone (GH ... the researchers found that male mice lacking the GH receptor in a group of somatostatin-expressing neurons displayed increased anxiety. Somatostatin is a peptide that ...

Growth hormone (GH ... the researchers found that male mice lacking the GH receptor in a group of somatostatin-expressing neurons displayed increased anxiety. Somatostatin is a peptide that ...

today announced the initiation of a Phase 1 clinical trial of the Company’s peptide growth hormone receptor antagonist (GHRA), AZP-3813, which is being developed as a potential add-on to ...

Paltusotine, a somatostatin receptor type 2 (SSTR2) agonist, has a primary mechanism of action that focuses on inhibiting the release of growth hormone. However, this very specificity can be a ...

today announced the initiation of a Phase 1 clinical trial of the Company’s peptide growth hormone receptor antagonist (GHRA), AZP-3813, which is being developed as a potential add-on to somatostatin ...