The study is useful for advancing spatial transcriptomics through its novel regression-based linear model (glmSMA) that integrates single-cell RNA-seq with spatial reference atlases, though its ...

Every soft caress of wind, searing burn and seismic rumble is detected by our skin’s tangle of touch sensors. David Ginty has ...

By mapping the subcellular architecture and protein interactions within cells, researchers can better understand how mutations contribute to pediatric cancers and other conditions.

Scientists have attempted to map the human cell since the first microscope was invented more than 400 years ago. But many components of the cell still remain uncharted. " We know each of the ...

As much of cell structure remains uncharted, there has been long-standing interest in developing strategies to map this architecture systematically. The study presented a large-scale multimodal ...

Shihabeddin et al utilized single-cell RNA-Seq analysis of adult P23H zebrafish animals to identify transcription factors (e2fs, Prdm1a, Sp1) expressed selectively in neural progenitors and immature ...

Just like people, no two cancer cells ... single-cell omics has improved our understanding of cancer heterogeneity,” as single-cell omics data can highlight cell-to-cell diversity and map ...

Overall, we are optimistic about the doors our research and techniques are opening.” In this study, CHOP researchers used advanced single cell sequencing and spatial omics techniques to analyze the ...

Lipids in cell membranes regulate the activity of a cancer-linked protein, cell biologists at RIKEN have discovered. This finding, published in the journal eLife, could pave the way for novel ...