For the study, they focused on the SARS-CoV-2 spike protein—the part of the virus responsible for helping it enter human cells—and used a protein language model to predict potential new mutations in ...

Researchers develop quinoline-based drug with inhibitory activity against the SARS-CoV-2 papain-like protease (PLpro).

Researchers from Lawrence Livermore National Laboratory (LLNL), in collaboration with other leading institutions, have ...

CeSPIACE binds to the invariant region of the RBD in the spike protein, which is less likely to mutate, making it effective against mutant strains ...

Many philosophers and scientists have pondered if we live in a simulated universe, and University of Portsmouth scientist ...

“All pathogen proteins, like the SARS-CoV-2 spike, have invariant structures critical for their functions, making them good targets for mutation-tolerant drugs, as seen in our peptide ...

Influenza spreads mainly through the acquisition of mutations that allow it to evade people’s immunity. Because no one had ever been infected with SARS-CoV-2 before 2019, many scientists didn ...

Germinal centers rapidly introduce mutations into an otherwise average ... as exposure to the receptor-binding domain of the SARS-CoV-2 spike protein. "We learned that there are two mechanisms ...

COVID-19 has continued to alarm public health, and although several therapeutics and vaccines have been developed, the development of effective vaccines or antibodies is challenging due to mutations ...

The following is a summary of “A viro-immunological model to characterize the antiviral effect of molnupiravir in ...

The method first takes a given SARS-CoV-2 spike protein sequence and simulates all possible single-point mutations. For each mutated version of the protein, DNMS uses the ProtBERT model to ...