Nucleic acids are complex biological molecules that store and transmit ... to form the iconic double helix structure. RNA is usually single-stranded but can form complex secondary structures through ...

Levene made his initial proposal in 1919, discrediting other suggestions that had been put forth about the structure of nucleic acids. In Levene's own words, "New facts and new evidence may cause ...

A variety of chemical modifications decorate the nucleic acids, increasing the alphabet of DNA ... The different building blocks can affect the complementarity of the RNA molecules, alter their ...

In this review of RNA therapies, we paint an overview of what’s going on in a field that is addressing a number of diseases.

Non-Watson-Crick base pairs can play important roles in RNA secondary structure, protein-nucleic acid interactions, and genetic recoding events. The Role of Base Pairs in Genetics Base pairs play a ...

Determining structures of small, protein-free RNAs by cryo-EM has been challenging. Here, the authors use a group II intron scaffold to achieve high-resolution RNA structures, visualize ligand ...

LMU researchers have investigated how cationic polymers organize on a molecular level when transporting RNA drugs ... which all kinds of therapeutic nucleic acids can be encapsulated for secure ...

Saliva is a viable alternative source of nucleic acids. A new collection device offers stable and easy saliva collection for extracting both DNA and RNA from a single sample.

But the challenge is daunting: Each RNA molecule is tightly bound to ... helical nucleocapsid-like pseudo-atomic structure, Nucleic Acids Research (2024). DOI: 10.1093/nar/gkae1211 Provided ...

The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions ... (2014) Individual letters of the RNA polymerase II ...

metabolism at the post-transcriptional level via a novel small noncoding RNA to promote infection in the host's intestinal environment. Sialic acids are a family of alpha-keto acid sugars with a ...