Co. Ltd. has identified proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase binding moiety coupled to an androgen receptor targeting moiety through a linker acting as androgen ...

Increland has identified proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to an interleukin-1 receptor-associated kinase 4 (IRAK-4) ...

For years, scientists have focused on amyloid beta buildup as the main culprit in Alzheimer’s disease, but a new study suggests the real problem might lie in a stalled protein-cutting process in the ...

A study of rare familial genetic mutations linked to early-onset dementia supports the idea that stalled protein processing contributes to Alzheimer’s disease.

School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, People’s Republic of China School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou ...

Proteolysis is the enzymatic process by which proteins are degraded into their component polypeptide or amino acid parts. This generally occurs through protease-mediated hydrolysis of peptide ...