This so-called "entropic destabilization" of the unfolded state is the main driver of how the ribosome alters the protein folding pathway via aiding the formation of co-translational folding ...

Newly synthesized proteins fold into their three-dimensional structures with the help of a series of molecular chaperones and folding catalysts ... sent along another pathway (the unfolded ...

As discussed already, misfolded proteins result when a protein follows the wrong folding pathway or energy-minimizing funnel, and misfolding can happen spontaneously. Most of the time, only the ...

"Starting from predicted static ground-state structures, the new method generates alternative structures and pathways ... the folding, called local frustration, are essential for protein ...

The protein initially contains a so-called "intein," which removes itself from the peptide chain to ensure the correct folding and function of the final protein. A team led by protein chemist Prof ...

A team of Chinese researchers led by Prof. WANG Likun from the Institute of Biophysics of the Chinese Academy of Sciences has provided new insights into metabolic disease mechanisms and potential ...

Edaravone may exert its neuroprotective effects in ALS by also correcting the abnormal localization of TDP-43, a key ...

Depending on specific circumstances, adoption of hydrophobic or amphipathic helical structure on binding to the membrane surface may be followed by membrane insertion, resulting in transmembrane ...