In a study published in Angewandte Chemie International Edition, a research team integrated activity-based protein profiling ...

Neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS (amyotrophic lateral sclerosis) are debilitating conditions ...

Summary: Scientists have discovered a new protein pathway involved in neurodegeneration by studying “mini-brain” organoids made from patients with frontotemporal lobar degeneration (FTLD). They found ...

Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel The Center for Physics and Chemistry of Living Systems, Tel Aviv University, Tel Aviv 6997801, ...

Although the work is preliminary, the pathway is a potential therapeutic ... post-translational modification and folding, every protein-coding gene can give rise to multiple proteoforms, each ...

The heat shock protein family A member 5 (HSPA5), commonly known as 78 kDa glucose-regulated protein (GRP78), played a pivotal role in various human ailments, including infections and tumorigenesis ...

Cell membrane proteins hide secret gateways that can be ... These newly identified pathways could be leveraged to develop innovative therapeutic treatments. According to Dr. David Aranda ...

Previously unknown access points in cell membrane proteins have been discovered ... These newly identified pathways could be leveraged to develop innovative therapeutic treatments.

RPL9 KD notably elevated p53 protein expression relative to the control group (Figures 4I, J). The findings indicate that RPL9 KD trigger nucleolar stress and activates the p53 signaling pathway in ...