This so-called "entropic destabilization" of the unfolded state is the main driver of how the ribosome alters the protein folding pathway via aiding the formation of co-translational folding ...

Newly synthesized proteins fold into their three-dimensional structures with the help of a series of molecular chaperones and folding catalysts ... sent along another pathway (the unfolded ...

As discussed already, misfolded proteins result when a protein follows the wrong folding pathway or energy-minimizing funnel, and misfolding can happen spontaneously. Most of the time, only the ...

The endoplasmic reticulum (ER) is the portion of the cell responsible for manufacturing and folding proteins. Proteins are ...

Depending on specific circumstances, adoption of hydrophobic or amphipathic helical structure on binding to the membrane surface may be followed by membrane insertion, resulting in transmembrane ...