[59] Larger trials are necessary to confirm the existence of platelet resistance to prasugrel and to describe the possible underlining mechanisms. Elinogrel (PRT060128 or PRT128) (Figure 3 ...

have defects in platelet secretion, fibrinogen binding, and stable aggregate formation. Akt2-/- mice are also resistant to thrombosis in an arterial injury model. In contrast, the Akt substrate, ...