Objective This study aims to evaluate the role of antiphospholipid antibodies (aPLs) in patients with SLE with heart valve ...

Rallybio Corporation (Nasdaq: RLYB), a clinical-stage biotechnology company translating scientific advances into ...

A platelet transcriptome analysis from patients with antiphospholipid syndrome indicated an upregulation of the mTORC2–Akt signalling pathway. 42 Sin1 (also known as MAPKAP1) deficiency disrupted the ...

platelet factor 4 (PF4/CXCL4), have been described in heparin-induced thrombocytopenia (HIT), but also in patients positive for antiphospholipid antibodies (aPL) even in the absence of heparin ...

as well as with higher procoagulant activity (phospholipid-dependent clotting time on day 15: P =.016). “Our results indicate that cold-stored platelets perform better than those stored at room ...

Antiphospholipid (aPL) antibodies activate platelet, endothelial cells and monocytes involving p38 MAPK. Tissue factor is an important procoagulant molecule upregulated by aPL antibodies in ...

These antibodies (aPL) can also cause other clinical problems such as thrombocytopenia (low platelet counts) or heart valve disease. Antiphospholipid antibodies occur in otherwise healthy individuals ...

Antiphospholipid antibodies (aPLs) have been reported to be involved in platelet‐mediated thrombosis and inflammation, but the impact on the prognosis of ischemic stroke remains unclear. We aimed to ...

Antiphospholipid antibody positivity among patients with ... An increase in the number of aPL types was associated with lower baseline (P <.001) and minimum (P =.001) platelet values. Additionally, ...

When the platelet count is low, it can result in difficulties in blood clotting, leading to potential bleeding or bruising. The precise cause of thrombocytopenia in patients with antiphospholipid ...

People with lupus and low platelets also tend to experience: neuropsychiatric disorders kidney conditions hemolytic anemia antiphospholipid syndrome Severely low platelet counts may increase your ...