Platelets, generated from precursor megakaryocytes (MKs), are central mediators of hemostasis and thrombosis. The process of thrombopoiesis is extremely complex, regulated by multiple factors, and ...

Platelet-rich plasma (PRP) has been applied as a popular non-operative treatment option for promoting musculoskeletal healing. Our previous work demonstrated that PRP protected chondrocytes from ...

A new study by University of Tuebingen researchers published on the preprint server medRxiv* in September 2020 shows the strong association between platelet apoptosis and the thrombotic ...

Here we show that the platelets undergo apoptosis in ITP patients with anti-GPIbα autoantibodies. We demonstrate that anti-GPIbα antibody binding activates Akt, which elicits platelet apoptosis ...

Platelet transfusion can elicit alloimmune responses leading to alloantibody formation against donor-specific polymorphic residues, ultimately resulting in platelet transfusion refractoriness.

As a result, focal apoptosis and even necrosis may be observed, leading to their infection, platelet aggregation, and peripheral destruction of platelets. Vascular permeability increases ...

induction of platelet mitophagy protects the platelet from apoptosis by removing the damaged mitochondria and preserves platelets function. Autophagy and mitophagy are increased in diabetic platelets.

Macrophage migration inhibitory factor (MIF) is released on platelet activation. Circulating MIF could potentially regulate platelets and thereby platelet-mediated inflammatory and regenerative ...

In a glucose dose–dependent manner, severe mitochondrial damage leads to loss of mitochondrial membrane potential and platelet apoptosis (cytochrome c release, caspase 3 activation, and ...

Here’s how it works. At the cellular level, death is essential for life. Apoptosis, sometimes called "cellular suicide," is a normal, programmed process of cellular self-destruction. Even though ...