Choice of statistical models and data integrity are vital A BMJ investigation by Doshi (doi:10.1136/bmj.r1201)1raises concerns about the integrity of two randomised trials with surrogate endpoints ...

A team led by the University of Sydney has identified red blood cell rupture at dying endothelial sites as a primary driver of microvascular obstruction in COVID-19, bypassing the expected role of ...

Mechanism of action of the P2Y 12 ... the platelet aggregation and the platelet-mediated inflammatory response in patients with a history of an ACS receiving long-term therapy with CB is ...

Garlic extract may reduce heart attack risk by 40%. Discover how this natural compound protects your heart and arteries from ...

New research has revealed that ginger's bioactive compounds possess significant potential as a natural treatment for cardiovascular disease. The study, published in Cureus, demonstrates that ginger ...

For the complete inhibition of platelet aggregation by aspirin, it is necessary to inhibit TxA 2 production by >90%, which can be achieved by a dosage as high as 30 mg/day. When platelets are ...

The concept of reverse ageing is related to your biological age, which is the age of the body on a physical and cellular level and not on the basis of the years you have been alive.These two ages- ...

In summary, TCM exhibit significant inhibitory effects on platelet activity. These effects can be effective in both the prevention and treatment of cardiovascular diseases through mechanisms such as ...

Activation of platelet P2RX1 by ATP can result in platelet shape change favoring adhesion while activation of P2Y1 and P2Y12 receptors by ADP can lead to increased platelet aggregation . Cytokines ...

However, the anti-platelet aggregation mechanism of natural compounds is not comprehensive. Therefore, we have elaborated the main pathways that affect platelet aggregation in terms of the adenosine ...