The start-up recently published a peer-reviewed paper describing a compound that prevented SARS-CoV-2 from replicating in mice by blocking the virus’s papain-like protease (PLpro), a target ...

Papain is an enzyme found in papaya, but it’s also available in other forms. Limited research suggests it may offer some health benefits, like improved digestion. Papain is a proteolytic enzyme ...

Parks explained that certain genes in the coronavirus genome are responsible for producing two enzymes inside the virus called proteases – the main protease and the papain-like protease (PLpro). Both ...

More information: Bin Tan et al, Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model, Science (2024). DOI: 10.1126/science.adm9724.

Similarly, SARS-CoV nsp3 is a major protein of 1922 amino acids, thought to have at least seven domains: (1) N-terminal Glu-rich acidic (AD) domain; (2) X domain (XD) with poly binding (ADP-ribose) ...

It was announced Tuesday that the collaboration will aim “to advance discovery and development of novel papain-like protease (PLpro) inhibitors and potentially introduce a new class of oral ...

Papain-like protease (PLpro) is SARS-CoV-2’s other essential cysteine enzyme. Like the main protease, PLpro is critical to viral replication and assembly, ...

Agreement aims to advance discovery and development of novel papain-like protease (PLpro) inhibitors and potentially introduce a new class of oral antivirals in the fight against COVID-19 Expands ...

The proteins are initially tethered together, like pieces of a plastic model that need to be punched out of their mold. ... known to scientists as papain-like protease, or PLpro.

The focus of the partnership will be on possible inhibitors of the SARS-CoV-2 papain-like protease (PLpro), which similar to the main protease (Mpro), is needed for viral replication.

Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease; Vasundara Srinivasan et al.; Communications Biology, 2022; DOI: 10.1038/s42003 ...

Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease. Communications Biology , 2022; 5 (1) DOI: 10.1038/s42003-022-03737-7 Cite This ...