The "Poverty, Prosperity, and Planet. Pathways Out of the Polycrisis" report evaluates progress towards these goals. It offers the first global assessment of poverty and shared prosperity ...

Given the central role of B cells in pSS pathogenesis, we investigated PI3Kδ pathway activation in pSS and the functional consequences of blocking PI3Kδ in a murine model of focal sialoadenitis that ...

In this review, we also discuss the current status and perspective of clinical trials on glioblastoma based on the CD95-CD95L signaling pathway. Glioblastoma (GBM) is the most common and aggressive ...

PI3K signaling pathways. Upon activation by RTK, GPCR, Integrin, and Ras, p110 loses inhibition by p85 and converts PIP2 to PIP3. PIP3 recruits AKT to the cell membrane, where AKT is activated ...

At Trinity, many of our programmes offer pathways to give you the flexibility to focus or expand your areas of interest over your years at Trinity. As a Trinity student, you will have choices to make ...

In a surprising discovery, scientists have found that the heart possesses "sweet taste" receptors, similar to those on our tongues, and that stimulating these receptors with sweet substances can ...

These variants control several common biological pathways, including those governing whether and how well a cell can repair damage to its DNA, how it produces energy, and how it interacts with and ...

Lowering oxysterol, in both animal models and human stem cells, freed the trapped ABCA1 and restored the pathway to its healthy state. Lowering oxysterol could be a new way to prevent or treat ...

The National Academies of Sciences, Engineering, and Medicine are private, nonprofit institutions that provide expert advice on some of the most pressing challenges facing the nation and world. Our ...

Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary, IRDR International Center of ...