More than half of human cancers involve mutations in the p53 tumor-suppressor gene, specifically in its DNA-binding core domain, pointing to this region of the p53 protein as being pivotal to its ...

Researchers at the Wistar Institute successfully determined, and reported in the July 21 issue of the Journal of Biological Chemistry, the three-dimensional structure of the p53 protein bound as a ...

Previous studies showed that p53 executes most of its functions as a dimer of dimers to create a DNA-binding tetramer unit, though others indicated that p53 dimers, splice variants, or interactions ...

The p53 protein was visualized using an enhanced chemiluminescent technique (ECL kit, Amersham). ... The 3D-structure p53 tetramerization domain was based on 3SAK (PDB) ...

The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity. EMBO J 25 : 5191–5200. Article CAS Google Scholar ...

By adding a spider silk protein to p53, they show that it is possible to create a protein that is more stable and capable of killing cancer cells. The study is published in the journal Structure.

By adding a spider silk protein to p53, they show that it is possible to create a protein that is more stable and capable of killing cancer cells. The study is published in the journal Structure.

The study is published in the journal Structure in a paper titled, “A ‘spindle and thread’-mechanism unblocks p53 translation by modulating N-terminal disorder.” “Disordered proteins ...

Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress. Nature Communications , 2016; 7: 11390 DOI: 10.1038/ncomms11390 Cite This Page : ...

FREE Webinar. Tuesday, June 30, 2020 2:30 - 4:00 PM, Eastern Standard Time. Register Now. Since its discovery by Arnold Levine in 1979, the tumor protein p53 has transformed the field of cancer ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...