The tiny protein known as transthyretin can cause big problems in the body when it misfolds after secretion. While healthy ...

Monoclonal antibodies, or mAbs, are important tools in medicine. These laboratory-made proteins are widely used in treatments ...

To directly examine the interplay between mutant p53 or Mdm2 and wild type p53 in gene occupancy and expression, an integrated RNA-seq and ChIP-seq analysis was performed in vivo using isogenically ...

Proteins, the pillars of cellular function, often assemble into 'complexes' to fulfill their functions. A study reveals why this assembly often begins during the very process of protein synthesis or ...

These insights could drive the development of new drugs to treat transthyretin amyloidosis, a progressive and fatal disease.

A prominent research group from Ehime University and its close partner at Kiel University have published their third ...

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

Research on the development, physiology and pathophysiology of reproductive disorders is important, as evidence suggests that many adult-onset diseases can be traced back to disruptions during early ...

Best whey-protein powders Best collagen-protein powder Best plant-based protein powders All the other protein powders I’ve tried Protein powders can be found in thousands of formulations on tens ...

Uniform protein labeling in intact tissues is a challenge. An approach that allows antibodies to seep within organs could ...

Figure 2: Several trafficking signals localize regulatory proteins to the right place at the right time. Taken together, epigenetic changes that alter chromatin structure have surpassed the proof ...