Canada Gairdner Awards recognize the world’s most accomplished researchers whose work is improving our understanding of human ...

This manuscript demonstrates that Oct4 overexpression synergizes with Notch inhibition (Rbpj knockout) to promote the conversion of adult murine Müller glia (MG) into bipolar cells. These findings are ...

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...

The NOTCH family includes four receptors (NOTCH1-4) and interacts with ligands like Delta-like (DLL) and Jagged (JAG). NOTCH signaling can be canonical or noncanonical. Canonical signaling involves ...

The AMPA group of brain receptors have mostly been assumed to be calcium impermeable and so were not thought to contribute to the calcium-dependent mechanisms underlying learning and memory.