New research has investigated the mechanism by which bivalency functions to poise genes for expression during cell differentiation, providing insight into a long-standing paradigm in the regulation of ...

A group of scientists in China has revealed a novel mechanism whereby a short form of IL-18, generated by caspase-3 cleavage ...

As well as being essential in the precise packaging of DNA into the space of the nucleus, histone proteins are also the site ...

How do bacteria—harmless ones living in our bodies, or those that cause disease—organize their activities? A new study, ...

As many as 40% of Americans are obese, putting them at an increased risk for high blood pressure, diabetes, stroke, heart disease and certain cancers, according to the CDC. New research from the ...

Northwestern Medicine investigators have discovered a novel mechanism that recognizes and eliminates "bad" transcriptional ...

A research team has identified the core gene expression networks regulated by key proteins that fundamentally drive phenomena such as cancer development, metastasis, tissue differentiation from stem ...

Biology has yet to tap into the full benefits of computer simulations, but a new AI foundation model developed by a team of scientists including CMU's Eric Xing hopes to change that.

The TP53 gene is a gene that is mutated in many cancers ... binding of MDM2 to TP53), phytonutrients in some plant-based foods may directly reduce MDM2 expression. A number of natural products have ...

eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that ...

The first human trial of insulin-producing cells that have been gene-edited to evade immune attack is a success so far. The cells have survived and produced insulin for a month after being ...