Researchers have pinpointed the precise pathway in the brain that suppresses pain in times of threatening situations.

Patients with type 2 diabetes mellitus are at a higher risk of developing heart failure compared with the healthy population. In recent landmark clinical trials, sodium-glucose co-transporter 2 (SGLT2 ...

The cellular composition and underlying spatiotemporal transformation processes of subchondral bone in osteoarthritis (OA) remain unknown. Herein, various cell subsets from tibial plateau of patients ...

NSAIDs share both beneficial and adverse effects due to the same mechanism of action, i.e. the inhibition of cyclooxygenase (COX) ...

The mechanism of COX inhibition varies among NSAIDs. The human whole-blood assay is recommended for determining COX selectivity, but problems with poor predictability of IC 50 values in terms of ...

The mechanism of action (MoA) of a clickable fatty acid analogue 8-(2-cyclobuten-1-yl)octanoic acid (DA-CB) has been investigated for the first time. Proteomics, metabolomics, and lipidomics were ...

Arterial stiffness is a growing epidemic associated with increased risk of cardiovascular events, dementia, and death. Decreased compliance of the central vasculature alters arterial pressure and flow ...

The prevention of unplanned pregnancies is a global problem that requires immediate attention. The livelihoods of both men and women are affected by this issue. The best way to prevent unplanned ...

Citation: Newly discovered mechanism of mitochondrial dysfunction in obesity may drive insulin resistance and type 2 diabetes (2025, May 30) retrieved 24 June 2025 from https://medicalxpress.com ...

The cross-correlation of high-frequency ambient noise (>1 Hz) is usually interpreted as the empirical Green’s function between two stations and used for imaging the near surface. However, ...

DNA replication is a fundamental process required of all cell types (1–3).Replicative polymerases (Pol), such as the leading-strand polymeraseε (Polε) and lagging-strand Polδ, synthesize DNA with ...