RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho-ku, Nagoya 467-8603 ...

Work revealed that he culprit is an enzyme called PLA2G15. In a cellular model of the neurodegenerative disease Niemann-Pick Disease type C, or NPC1, the scientists determined whether this degradation ...

They focused on Niemann-Pick Disease type C, or NPC1—a genetic disorder sometimes referred to as "childhood Alzheimer's" that impacts cells' ability to distribute cholesterol through the ...

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States Biomedical Sciences Graduate Program, University of California, ...

Individuals with the lysosomal storage disorder Niemann–Pick type C1 (NPC1) carry a mutation in the gene that encodes a protein called NPC1. Cells from people with the disease have defects in ...

79978), KDM5A (Bethyl Labs A300-897A), KDM5B (Bethyl Labs A301-813A), KDM5C (Bethyl Labs A301-034A), XPF (Cell Signaling 13465), and Calnexin (Cell Signaling 2679). Secondary antibodies used were anti ...

NEWARK, N.J., May 05, 2025 (GLOBE NEWSWIRE) -- Rafael Holdings, Inc. (NYSE: RFL; NYSE American: RFL-WT) today announced revised subscription rights in connection with its previously announced ...

Protein editing was first demonstrated using model proteins including calnexin and β-actin. Successful insertion of new amino acid sequences into these proteins was confirmed using immunoblotting ...