BmE cells (2 × 10 5 cells/well) seeded in twelve-well culture plates were incubated with one of the following antibodies: mouse anti-NPC1-A, anti-NPC1-I polyclonal antibody, rabbit anti-NPC1-C ...
Background: Genetic studies have implicated the NPC1 gene (Niemann Pick type C1) in susceptibility to obesity. Methods: To assess the potential function of NPC1 in obesity, we determined its ...
TFEB overexpression or pharmacological activation of TFEB ameliorates cholesterol accumulation in U18666A-induced HeLa NPC1 model. A working scheme to illustrate that small-molecule TFEB agonist ...
The TransportNPC™ study is considered the most comprehensive of its kind concerning patient size, global reach, duration, and clinical outcomes for NPC1 treatment. The stock has shown resilience with ...
Ng, Ndungo, Kaczmarek et al. went on to discover some changes in the genome sequence of Ebola virus that could compensate for the changes in the bat’s NPC1 gene. These findings hint at one way that a ...
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