a low intracellular calcium ion concentration is maintained and the tropomyosin-troponin complex suppresses interaction between molecular motor myosin and actin filament (F-actin); this is termed ...

In the resting state, tropomyosin and troponin block the binding site for myosin on the actin filament. At this point, the myosin head is at a 90-degree position. Only after an influx of calcium ...

Calcium is required by two proteins, troponin and tropomyosin, that regulate muscle contraction by blocking the binding of myosin to filamentous actin. In a resting sarcomere, tropomyosin blocks ...

They also discovered the mechanism by which these filaments regulate heart beat via cardiac muscle contractions in the presence or absence of calcium ions by changing their conformations.

The sarcomere is the most basic contractile unit in skeletal and cardiac muscle. Mutations in genes encoding sarcomeric proteins give rise to heritable myopathies, although muscle function is more ...

They also discovered the mechanism by which these filaments regulate heart beat via cardiac muscle contractions in the presence or absence of calcium ions by changing their conformations.

The ability to modify the intracellular concentrations of divalent calcium ions is vital to normal cell functioning. In the cells of the cardiac muscle, calcium ions play a crucial role in ...

This study investigates the role of a key interaction between Tropomyosin ... calcium levels, with conformational changes occurring at a threshold of pCa 6, enabling myosin-actin cross-bridge cycling ...

The cardiac muscle contraction-relaxation cycle is dependent on alterations to intracellular calcium levels. In the absence of Ca2+, tropomyosin ... by Ca2+ binding to Troponin C, allowing Tpm ...

They also discovered the mechanism by which these filaments regulate heart beat via cardiac muscle contractions in the presence or absence of calcium ions by changing their conformations.