They may also have peripheral lymphocytosis, monocytosis and/or eosinophilia. Anemia and thrombocytopenia have also been frequently reported.

Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic malignancy that is characterized by dysplasia, peripheral monocytosis, ineffective hematopoiesis, and an increased risk of ...

BACKGROUND: Sipa1 (signal-induced proliferation-associated gene 1) is known as a specific Rap1 GTPase-activating protein that negatively regulates Rap1 signaling. Although Sipa1 has been extensively ...

The growing worldwide health challenge of atherosclerosis, together with advances in imaging technologies, have stimulated considerable interest in novel approaches to gauging this disease. The last ...

Cancers generate complex immunologic stressors that can alter the myelopoietic output, leading to the formation of heterogeneous myeloid cell populations [i.e., tumor-associated macrophages (TAM) and ...

Introduction: Cardiofaciocutaneous syndrome (CFCS) is a rare syndromic disorder caused by germline mutations affecting the RAS/MAPK pathway. It is characterized by distinctive craniofacial dysmorphism ...