New research reveals that neurons can switch their migration strategy depending on whether they move on flat surfaces or through tight, crowded spaces.

Scientists say they have discovered how a group of proteins linked to Parkinson's disease and amyotrophic lateral sclerosis act as 'guardians' of mitochondria, small organelles, or subunits, within a ...

Integral membrane proteins such as receptors and ion channels span the membrane. Peripheral membrane proteins, for example some signalling proteins, are tethered by an anchor, via a fatty acid ...

A precision medicine workflow integrating proteomics and personalized xenograft models was developed and applied to an ...

G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

All those figures are about the same as last year’s. Here are the key trends and themes that we saw (or did not see): * Protein is still huge. People apparently feel they cannot get enough (or so ...

Molecular dynamics (MD) simulations of membrane proteins cover a wide range of applications and specialized techniques. These techniques accurately combine two challenges into one: properly capturing ...

So far, we know that the prion protein can act as a scaffold, creating multiprotein signaling platforms in the membrane of cells so that they can survive and proliferate. When we altered the ...

School of Chemistry, University of Leeds, Leeds LS2 9JT, U.K. Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K. School of Chemistry, University of Leeds, Leeds ...

Nearly 25% of human genes encode transmembrane proteins that span the entire membrane from one side to the other, helping the membrane perform its roles. Transmembrane proteins are synthesized by ...

Monotopic membrane proteins integrate into the lipid bilayer via reentrant hydrophobic domains that enter and exit on a single face of the membrane. Whereas many membrane-spanning proteins have been ...